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KMID : 0384119860060020367
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Korean Journal of Clinical Pathology
1986 Volume.6 No. 2 p.367 ~ p.373
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A Study on the Bone Marrow Involvement of Metastatic Tumor
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Abstract
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The results of examination of 204 bone marrow aspirates and biopsies of 199 patients with known or suspected malignant tumors are presented.
Of the 199 patients, 81(40.7/) showed metastatic tumor. Of these, metastases were most frequent in stomach carcinoma (84.6/), breast carcinoma(80.0%), neuroblastoma (61.5 /) , Ewing´s sarcoma (44.4 `0), hepatoblastoma (16.7 %) , small cell carcinoma (g.1 /) , others (16.7 /) and unknown primaries (62. 5%) .
The bone marrow biopsy was superior to the aspirate in finding metastatic tumor (98/ vs 88/).
Both extensive tumor involvement and moderate myelofiblosis were presented in over half of all positive biopsies.
Osseous remodelling was found in over 70,0/c of biopsies with metastases though either bone formation or resorption or mixed.
Metastases presented in the bone marrow without any abnormalities being recognized in bone scans, radiographic] picture, serum chemistry or hematological parameters.
This study demonstrates the usefulness of combining biopsy and smear examinations for increased detection of unsuspected ;bone marrow metastases in staging of malignant tumors.
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KEYWORD
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